免疫系统
C型凝集素
凝集素
抗原
聚糖
西格莱克
生物
细胞生物学
巨噬细胞
化学
糖蛋白
生物化学
免疫学
体外
作者
Berna Tumoglu,Aidan P. Keelaghan,Fikri Y. Avci
出处
期刊:Glycobiology
[Oxford University Press]
日期:2023-10-17
卷期号:33 (11): 879-887
被引量:1
标识
DOI:10.1093/glycob/cwad083
摘要
Abstract Protein-carbohydrate interactions are essential in maintaining immune homeostasis and orchestrating inflammatory and regulatory immune processes. This review elucidates the immune interactions of macrophage galactose-type lectin (MGL, CD301) and Tn carbohydrate antigen. MGL is a C-type lectin receptor (CLR) primarily expressed by myeloid cells such as macrophages and immature dendritic cells. MGL recognizes terminal O-linked N-acetylgalactosamine (GalNAc) residue on the surface proteins, also known as Tn antigen (Tn). Tn is a truncated form of the elongated cell surface O-glycan. The hypoglycosylation leading to Tn may occur when the enzyme responsible for O-glycan elongation—T-synthase—or its associated chaperone—Cosmc—becomes functionally inhibited. As reviewed here, Tn expression is observed in many different neoplastic and non-neoplastic diseases, and the recognition of Tn by MGL plays an important role in regulating effector T cells, immune suppression, and the recognition of pathogens.
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