怀孕
激素
神经科学
生物神经网络
预测(人工智能)
兴奋性突触后电位
人口
内分泌学
生物
内科学
下丘脑
神经元回路
医学
抑制性突触后电位
遗传学
环境卫生
人工智能
计算机科学
作者
Rachida Ammari,Francesco Monaca,Mingran Cao,E Nassar,Patty T. Wai,N. Del Grosso,Matthew Lee,Neven Borak,Deborah Schneider-Luftman,Johannes Kohl
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-10-06
卷期号:382 (6666): 76-81
被引量:17
标识
DOI:10.1126/science.adi0576
摘要
During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of estradiol and progesterone on galanin (Gal)–expressing neurons in the mouse medial preoptic area (MPOA) is critical for pregnancy-induced parental behavior. Whereas estradiol silences MPOA Gal neurons and paradoxically increases their excitability, progesterone permanently rewires this circuit node by promoting dendritic spine formation and recruitment of excitatory synaptic inputs. This MPOA Gal -specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. Pregnancy hormones thus remodel parenting circuits in anticipation of future behavioral need.
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