特发性肺纤维化
医学
疾病
遗传建筑学
清晰
发病机制
肺纤维化
遗传倾向
生物信息学
纤维化
遗传学
免疫学
病理
生物
内科学
环境卫生
肺
数量性状位点
人口
生物化学
出处
期刊:Chest
[Elsevier]
日期:2023-10-01
卷期号:164 (4): 818-819
被引量:1
标识
DOI:10.1016/j.chest.2023.05.015
摘要
Extensive efforts have provided clarity regarding the complex genetic architecture underlying idiopathic pulmonary fibrosis (IPF). A multitude of genes and variants have been discovered that implicate a host of biologic processes that contribute to IPF pathogenesis. Apart from uncovering potential disease mechanisms, genetics research offers the opportunity to quantify disease susceptibility risk. However, only a portion of IPF cases harbor an implicated genetic variant, which creates a gap between genetic risk and the prevalence of established disease.
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