生物
史前史
基因流
古代DNA
人口
基因组
遗传学
进化生物学
遗传变异
人口学
基因
社会学
古生物学
作者
Ke Wang,Kay Prüfer,Ben Krause‐Kyora,Ainash Childebayeva,Verena J. Schuenemann,Valentina Coia,Frank Maixner,Albert Zink,Stephan Schiffels,Johannes Krause
出处
期刊:Cell genomics
[Elsevier]
日期:2023-09-01
卷期号:3 (9): 100377-100377
被引量:1
标识
DOI:10.1016/j.xgen.2023.100377
摘要
The Tyrolean Iceman is known as one of the oldest human glacier mummies, directly dated to 3350–3120 calibrated BCE. A previously published low-coverage genome provided novel insights into European prehistory, despite high present-day DNA contamination. Here, we generate a high-coverage genome with low contamination (15.3×) to gain further insights into the genetic history and phenotype of this individual. Contrary to previous studies, we found no detectable Steppe-related ancestry in the Iceman. Instead, he retained the highest Anatolian-farmer-related ancestry among contemporaneous European populations, indicating a rather isolated Alpine population with limited gene flow from hunter-gatherer-ancestry-related populations. Phenotypic analysis revealed that the Iceman likely had darker skin than present-day Europeans and carried risk alleles associated with male-pattern baldness, type 2 diabetes, and obesity-related metabolic syndrome. These results corroborate phenotypic observations of the preserved mummified body, such as high pigmentation of his skin and the absence of hair on his head.
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