Effect of vortioxetine versus venlafaxine on cognitive functions in adults with major depressive disorder: A randomized-controlled trial

沃替西汀 文拉法辛 斯特罗普效应 重性抑郁障碍 心理学 精神科 蒙哥马利-奥斯伯格抑郁评定量表 随机对照试验 认知 临床心理学 医学 内科学 焦虑 抗抑郁药
作者
Chayan Kanti Manna,Rajeev Ranjan,Pankaj Kumar,Shamshad Ahmad,Santanu Nath
出处
期刊:Indian Journal of Psychiatry [Medknow Publications]
卷期号:65 (8): 815-824 被引量:2
标识
DOI:10.4103/indianjpsychiatry.indianjpsychiatry_160_23
摘要

ABSTRACT Background: Vortioxetine and venlafaxine are antidepressants which have shown established efficacy to treat major depressive disorder (MDD). There are no studies that compared them for their efficacy in cognitive symptoms of depression. The study aimed to compare the effect of vortioxetine and venlafaxine on the change in cognitive scores in adults with MDD. Methods: The present study was an open-label, active-controlled parallel design randomized clinical trial. After randomization, baseline clinical evaluations by Montgomery–Asberg Depression Rating Scale (MADRS) and Social and Occupational Functioning Assessment Scale (SOFAS) were done and coding (subset of WAIS-IV), WCST, TMT, Stroop test, PGI memory were used to assess cognition in 100 unmedicated MDD patients. They were reassessed after eight weeks of monotherapy with vortioxetine or venlafaxine. Results: Primary cognitive measure (coding score) was found to be significantly higher (Mean Difference = 0.680; 95% CI:.202 to 1.158; P = 0.006) in vortioxetine in comparison with venlafaxine. Stroop test scores (word score, color score, color–word score) were also found to be significantly higher with vortioxetine. In other cognitive measures (WCST scores: total trials, total errors score, total perseverative responses score, total perseverative errors scores; TMT-A and B scores), a significant decrease in scores with vortioxetine in comparison with venlafaxine were observed. A significant decrease in MADRS and increase in SOFAS scores were observed with vortioxetine in comparison with venlafaxine. Both the drugs alleviated the symptoms of depression but vortioxetine was better tolerated. Conclusion: Our study findings suggest that improvement in cognitive scores is significantly higher with vortioxetine than venlafaxine over the eight weeks of monotherapy. Clinical Trial registration number: CTRI/2020/07/026819 (Registered with Clinical Trials Registry- India).
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