Association between systemic immune-inflammation index and serum uric acid in U.S. adolescents: A population-based study

医学 内科学 免疫系统 人口 尿酸 全身炎症 联想(心理学) 免疫学 炎症 心理学 环境卫生 心理治疗师
作者
Feng Xie,Zhijian Wu,Jie Feng,Kai Li,Meng Li,Yanqing Wu
出处
期刊:Nutrition Metabolism and Cardiovascular Diseases [Elsevier BV]
卷期号:34 (1): 206-213 被引量:7
标识
DOI:10.1016/j.numecd.2023.10.008
摘要

Background and aims Serum uric acid (SUA) has been reported to be associated with inflammation, and elevated SUA is increasingly prevalent in adolescents. The systemic immune-inflammation index (SII) is an innovative and integrated inflammatory indicator that has not yet been studied with SUA in adolescents. We therefore aimed to investigate the potential relationship between SII and SUA in U.S. adolescents. Methods and results A total of 5,568 adolescents aged 12–19 years from NHANES 2009–2018 were analyzed. SII was calculated as platelet count × neutrophil count/lymphocyte count. Elevated SUA was defined as ≥ 5.5 mg/dL. SII was Ln-transformed for analysis for the skewed distribution. Multivariate linear and multiple logistic regression analyses were conducted to explore the association of SII with SUA and elevated SUA. A generalized additive model and a fitted smoothing curve were also performed. The prevalence of elevated SUA was 35.4%. Multivariate linear regression analyses indicated that LnSII was positively associated with SUA level (β = 0.15, 95% CI: 0.09–0.20). Multiple logistic analyses indicated that LnSII was associated with a 38% increased risk of elevated SUA (OR = 1.38, 95% CI: 1.11–1.70). The smooth curve fitting showed that the associations of LnSII with SUA and elevated SUA were linear. Besides, subgroup analyses showed a stronger association between LnSII and SUA in adolescents aged ≥ 17 years (P for interaction < 0.05). Conclusions SII was positively associated with SUA level and elevated SUA in U.S. adolescents, particularly in populations aged ≥ 17 years.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
童绾绾发布了新的文献求助10
刚刚
are完成签到,获得积分10
刚刚
刚刚
刚刚
2秒前
2秒前
Carrie完成签到,获得积分10
3秒前
敏感安柏发布了新的文献求助10
3秒前
3秒前
lijiaxin应助1177采纳,获得10
4秒前
打打应助科研通管家采纳,获得10
4秒前
大个应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
wanci应助科研通管家采纳,获得10
4秒前
丘比特应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
SYLH应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
4秒前
慕青应助科研通管家采纳,获得10
4秒前
4秒前
武雨寒发布了新的文献求助10
5秒前
乐乐应助美好斓采纳,获得10
5秒前
6秒前
6秒前
lu完成签到,获得积分10
7秒前
IFCOCO完成签到,获得积分10
7秒前
四火发布了新的文献求助10
7秒前
wang完成签到,获得积分10
7秒前
李瑞康发布了新的文献求助10
8秒前
8秒前
babayaga发布了新的文献求助10
9秒前
呆萌冰绿完成签到,获得积分10
10秒前
零一发布了新的文献求助10
11秒前
小葡萄icon完成签到 ,获得积分10
11秒前
韩涵发布了新的文献求助10
11秒前
viviannne发布了新的文献求助10
11秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975871
求助须知:如何正确求助?哪些是违规求助? 3520207
关于积分的说明 11201502
捐赠科研通 3256611
什么是DOI,文献DOI怎么找? 1798403
邀请新用户注册赠送积分活动 877552
科研通“疑难数据库(出版商)”最低求助积分说明 806430