肌萎缩侧索硬化
医学
队列
队列研究
回顾性队列研究
人口
电子健康档案
病历
疾病
儿科
内科学
医疗保健
环境卫生
经济增长
经济
作者
Richard J. Reimer,André Gonçalves,Braden Soper,José Cadena,Jennifer L. Wilson,Amy L. Gryshuk,Paola Suárez,Thomas F. Osborne,Kevin Grimes,Priyadip Ray
标识
DOI:10.1080/21678421.2023.2239300
摘要
Objective: To assemble and characterize an electronic health record (EHR) dataset for a large cohort of US military Veterans diagnosed with ALS (Amyotrophic Lateral Sclerosis). Methods: An EHR dataset for 19,662 Veterans diagnosed with ALS between January 1, 2000 to December 31, 2020 was compiled from the Veterans Health Administration (VHA) EHR database by a query for ICD9 diagnosis (335.20) or ICD10 diagnosis (G12.21) for Amyotrophic Lateral Sclerosis. Results: The cohort is predominantly male (98.94%) and white (72.37%) with a median age at disease onset of 68 years and median survival from the date of diagnosis of 590 days. With the designation of ALS as a compensable illness in 2009, there was a subsequent increase in the number of Veterans diagnosed per year in the VHA, but no change in median survival. The cohort included a greater-than-expected proportion of individuals whose branch of service at the time of separation was the Army. Conclusions: The composition of the cohort reflects the VHA population who are at greatest risk for ALS. The greater than expected proportion of individuals whose branch of service at the time of separation was the Army suggests the possibility of a branch-specific risk factor for ALS.
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