斑马鱼
生物
再生(生物学)
细胞生物学
脊髓
神经科学
脊髓损伤
中枢神经系统
信号转导
基因
生物化学
作者
Clayton J. Becker,Valentina Cigliola,Pierre Gillotay,Ashley Rich,Alessandro De Simone,Yanchao Han,Stefano Di Talia,Kenneth D. Poss
出处
期刊:Development
[The Company of Biologists]
日期:2023-11-24
摘要
Identification of signaling events that contribute to innate spinal cord regeneration in zebrafish can inform new targets for modulating injury responses of the mammalian central nervous system. Using a chemical screen, we identify JNK signaling as a necessary regulator of glial cell cycling and tissue bridging during spinal cord regeneration in larval zebrafish. With a kinase translocation reporter, we visualize and quantify JNK signaling dynamics at single-cell resolution in glial cell populations in developing larvae and during injury-induced regeneration. Glial JNK signaling is patterned in time and space during development and regeneration, decreasing globally as the tissue matures and increasing in the rostral cord stump upon transection injury. Thus, dynamic and regional regulation of JNK signaling help to direct glial cell behaviors during innate spinal cord regeneration.
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