间充质干细胞
脂肪组织
肿瘤坏死因子α
间质细胞
纤维化
癌症研究
基因
肿瘤坏死因子α
生物
医学
细胞生物学
病理
免疫学
内分泌学
遗传学
作者
Xianzhe Li,Guoqin Chen,Minghao Xie,Zhizhong Xiong,Shi Yin,Longyang Jin,Zhaoliang Yu,Caiqin Wang,Fengxiang Zhang,Dandong Luo,Jianping Guo,Dayin Huang,Haijie Tang,Huaxian Chen,Ping Lan,Lei Lian
标识
DOI：10.1016/j.intimp.2024.112693
摘要
The therapeutic potential of adipose-derived mesenchymal stromal cells (AMSCs) in the treatment of intestinal fibrosis occured in patients with Crohn's disease (CD) remains unclear. Tumor necrosis factor-stimulated gene 6 (TSG6) protein plays a critical role in inflammation regulation and tissue repair. This study aimed to determine if AMSCs attenuate intestinal fibrosis by secreting paracrine TSG6 protein and explore the underlying mechanisms.
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