膜性肾病
表位
抗原
免疫学
磷脂酶A2
T细胞
免疫疗法
医学
生物
肾小球肾炎
免疫系统
内科学
生物化学
酶
肾
标识
DOI:10.1016/j.kint.2022.12.018
摘要
The discovery of phospholipase A2 receptor 1 as the major target antigen in membranous nephropathy (MN) has initiated a decade of major advances in the understanding of MN pathophysiology and improvement of patient care. In this Issue, Zhang et al. identified potential T-cell epitopes of phospholipase A2 receptor 1 in patients with MN. The characterization of the pathogenic T- and B-cell epitopes on phospholipase A2 receptor 1 is an important step moving from the current unspecific immunosuppressive therapies toward antigen-specific MN treatments.
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