Therapeutic Approaches and Models in Retinoblastoma

In cancer research, animal models constitute an essential aspect of preclinical investigations. In various human malignancies, such as ovarian, breast, colon, liver cancers, and tumors in the eye, nonhuman tumor models have aided in determining the path of carcinogenesis and estimating diagnostic and treatments. In vitro investigations have limitations since they are done outside of the human body's complicated milieu. The complete scope of pathophysiological alterations that occur in neoplasms can be revealed by probing the cellular processes of tumor growth within the complexity of an organism. This chapter intends to construct prototypes that parodist all aspects of retinoblastoma, including its genesis, development, and metastasis, using molecular and imaging technology breakthroughs. In retinoblastoma research, combining xenograft and genetic models has and will support the way for a deeper understanding of retinoblastoma tumor biology and devising and testing viable diagnostic and therapy methods.