干细胞
伤口愈合
脂肪组织
血管生成
材料科学
生物医学工程
血小板源性生长因子受体
医学
癌症研究
细胞生物学
生长因子
外科
生物
内科学
受体
作者
Ye Xu,Xiangyi Wu,Xiaoxuan Zhang,Yan Zu,Qian Tan,Yuanjin Zhao
标识
DOI:10.1002/adfm.202209986
摘要
Abstract Stem cells have demonstrated values in diabetic ulcer (DU) treatments. Challenges in this area are focused on enhancing the localized curative effects of stem cells and improving diabetic wound healing efficiently. Herein, a novel living microneedle (MN) patch is presented as a localized delivery system of bioactive platelet derived growth factor D (PDGF‐D) and human adipose‐derived stem cells (ADSCs) for DU wound treatment. Compared with traditional complicated stem cell carriers, the MN patch can keep stem cell viability for ADSCs encapsulation and delivery, and possesses good mechanical strengths to penetrate the local skin wounds noninvasively. It is demonstrated that the delivery ADSCs are with the abilities of angiogenesis promotion during the DU wound healing; while the additive PDGF‐D can contribute significantly to the proliferation of ADSCs, strengthening the cell function of ADSCs and further facilitating the healing processes. Thus, living MN patches accelerate vascularization, tissue regeneration, and collagen deposition in a wounded diabetic mouse model, suggesting their potential application to DU wound healing and other therapeutic applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI