Enhanced Biological Behavior and Photothermal Antibacterial Performance of TiNbCTx MXene Modified Mesoporous Bioactive Glass Nanocomposites

Abstract Mesoporous bioactive glasses (MBGs) are gaining recognition in bone tissue engineering for their osteoblast differentiation‐inducing properties and customizable structures. However, the challenge of peri‐implantitis has hindered their broader application. To address this, double transition metal TiNbCT x MXene acted as near‐infrared (NIR) photothermal agent, has been integrated with MBG nanospheres to develop novel multifunctional TiNbCT x /MBG (TNC/MBG) nanocomposites in this work. The results demonstrate that the TNC/MBG composites feature uniform mesoporous spherical MBG nanoparticles on TiNbCT x nanosheets, boasting a significantly enhanced specific surface area of up to 444.74 m 2 g −1 and a more negative zeta potential than pristine MBG. Importantly, the TNC/MBG nanocomposites can effectively promote apatite formation, as well as the proliferation and viability of MC3T3‐E1 cells. Moreover, it is highlighted that the TNC/MBG nanocomposites display remarkable photothermal conversion efficiency and stability, leading to over 95% antibacterial inhibition rates against both S. aureus and E. coli under NIR irradiation. These findings offer an appealing strategy to develop multifunctional TNC/MBG nanocomposites with enhanced biological activity and robust antibacterial properties, which shows great potential for various biomedical applications.