生物
表观基因组
表观遗传学
干细胞
细胞生物学
转录组
祖细胞
骨骼肌
再生(生物学)
成体干细胞
细胞分化
DNA甲基化
遗传学
基因表达
解剖
基因
作者
Vittorio Sartorelli,Veronica Ciuffoli
标识
DOI:10.1101/gad.352277.124
摘要
Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In this review, we explore how metabolic pathways, metabolites, and transcriptional and epigenetic regulators are functionally interlinked in adult and aging skeletal muscle stem cells.
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