Sex Differences in Cardiovascular-Kidney-Metabolic Syndrome: 30-Year US Trends and Mortality Risks

医学 比例危险模型 人口学 危险系数 代谢综合征 内科学 置信区间 肥胖 社会学
作者
Hongwei Ji,Charumathi Sabanayagam,Kunihiro Matsushita,Ching‐Yu Cheng,Tyler Hyungtaek Rim,Bin Sheng,Huating Li,Yih‐Chung Tham,Susan Cheng,Tien Yin Wong
出处
期刊:Arteriosclerosis, Thrombosis, and Vascular Biology [Lippincott Williams & Wilkins]
被引量:4
标识
DOI:10.1161/atvbaha.124.321629
摘要

BACKGROUND: The American Heart Association recently published guidelines on how to clinically identify and categorize individuals with cardiovascular-kidney-metabolic (CKM) syndrome. The extent to which CKM syndrome prevalence and prognosis differ by sex remains unknown. This study aimed to examine the impact of sex on trends in prevalence over 30 years and the long-term prognosis of CKM syndrome in the United States. METHODS: We analyzed nationally representative National Health and Nutrition Examination Survey 1988 to 2018 data collected from 33 868 US adults (aged ≥20 years) who were under surveillance for all-cause mortality through December 31, 2019. We examined the sex-specific prevalence of CKM syndrome and sex-specific CKM associations with all-cause mortality. RESULTS: Of the 33 868 adults studied, the mean±SD age was 48.4±18.3 years with 52% women and 56% non-White. Overall prevalence of CKM syndrome increased steadily from 1988 to 2018 in both sexes, with a larger temporal rise in prevalent stage 3 CKM seen for males (from 18.9% to 22.4%) compared with women (from 13.9% to 15.2%). Over a median follow-up of 13.3 years, there were 8745 deaths. In the multivariable Cox regression analysis, worsening CKM severity was associated with all-cause mortality ( P <0.001 for both sexes), with greater magnitudes of risk seen in women (hazards ratio, 1.24–3.33) compared with men (hazards ratio, 0.85–2.60) across all stages (likelihood ratio test χ 2 , 19.0; P interaction <0.001); results were similar for cardiovascular mortality (likelihood ratio test χ 2 , 22.3; P interaction <0.001). CONCLUSIONS: Women, compared with men, exhibited a lower prevalence of CKM stage 3 but experienced excess mortality risk across the spectrum of multisystem CKM dysfunction. These findings underscore the importance of identifying mechanisms underlying joint cardiovascular, kidney, and metabolic system pathophysiology to close a potentially widening sex disparities gap in multiorgan disease risk.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hyl完成签到,获得积分10
刚刚
积极的初南完成签到,获得积分10
1秒前
Livrik发布了新的文献求助10
2秒前
小小完成签到 ,获得积分10
2秒前
笨笨山芙发布了新的文献求助10
3秒前
4秒前
4秒前
5秒前
5秒前
6秒前
7秒前
量子星尘发布了新的文献求助10
8秒前
Livrik完成签到,获得积分10
8秒前
小猴子关注了科研通微信公众号
8秒前
阿Q完成签到,获得积分10
9秒前
yujd完成签到,获得积分10
9秒前
鹿仪发布了新的文献求助10
9秒前
9秒前
9秒前
Orange应助好宝宝采纳,获得10
11秒前
11秒前
GL发布了新的文献求助10
12秒前
12秒前
李健应助年轻的烨华采纳,获得10
14秒前
Jasper应助zhugepengju采纳,获得10
14秒前
15秒前
酢浆草小熊完成签到 ,获得积分10
15秒前
沈昊泽完成签到,获得积分10
18秒前
陈浩发布了新的文献求助10
18秒前
19秒前
春眠不觉小小酥完成签到,获得积分10
20秒前
21秒前
22秒前
22秒前
wwb完成签到,获得积分10
22秒前
在水一方应助meimale采纳,获得10
23秒前
星晴遇见花海完成签到 ,获得积分10
24秒前
24秒前
24秒前
赘婿应助lize5493采纳,获得10
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035