Paralog Co-Targeting Identifies Selective Genetic Redundancies across Cancer Types

Summary: In this issue, Klingbeil and colleagues deploy a paralog co-targeting strategy to reveal microtubule affinity–regulating kinases 2 and 3 as redundant negative regulators of the Hippo pathway and potentially actionable targets in YAP/TAZ-addicted tumors. See related article by Klingbeil et.al., p. 2471