Advances in chalcone-based anticancer therapy: mechanisms, preclinical advances, and future perspectives

Introduction Cancerremains a leading cause of death worldwide with traditional treatments likechemotherapy, and radiotherapy becoming less effective due to multidrugresistance (MDR). This highlights the necessity for novel chemotherapeuticslike chalcone based compounds, which demonstrate broad anti-cancer propertiesand target multiple pathways. These compounds hold promise for improving cancertreatment outcomes compared to existing therapies.