多不饱和脂肪酸
医学
内科学
癌症
化学
生物化学
脂肪酸
作者
Jingshu Yang,Haiyan Wang,Xinting Zhang,S L Wang,Xiaojiang Duan,Qian Zhao,Ran Wang,Yao Wang,Hongshi Cao
出处
期刊:Journal of nutritional oncology
[Journal of Nutritional Oncology]
日期:2024-11-29
标识
DOI:10.1097/jn9.0000000000000046
摘要
Abstract Background The purpose of this report is to summarize the evidence supporting supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) in adult cancer patients, and to offer a better understanding of the appropriate use of n-3 PUFAs in the clinical setting. Methods Numerous databases were searched for guidelines, clinical decision-making documents, systematic reviews, expert consensus statements, and best evidence summaries about the use of n-3 PUFAs in cancer patients from the inception of the database to December 31, 2023. Evidence grading and recommendation rating were conducted. The data extracted included the timing of supplementation, symptom management, disease prevention, cost-effectiveness, route of administration, application scenarios, dosage, and safety. Results The collected data show that n-3 PUFAs are safe for patients receiving chemotherapy who are at risk of malnutrition and cachexia. Moreover, n-3 PUFA supplementation can alleviate the adverse symptoms associated with chemotherapy, extend survival, and improve the quality of life of patients with cancer. Conclusions The administration of supplementary n-3 PUFAs should be considered based on the patient’s disease stage, treatment plan, nutritional status, and tolerance, as well as the dosage, route and application scenarios. Promoting the clinical use of n-3 PUFAs may improve the outcomes for patients with cancer.
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