Unveiling Functional and Structural Brain MRI Alterations in Opioid Use Disorder

HomeRadiologyVol. 313, No. 3 PreviousNext Reviews and CommentaryEditorialUnveiling Functional and Structural Brain MRI Alterations in Opioid Use DisorderMassimo Filippi , Roberta MessinaMassimo Filippi , Roberta MessinaAuthor AffiliationsFrom the Neurology Unit and Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy; and Vita-Salute San Raffaele University, Milan, Italy.Address correspondence to M.F. (email: [email protected]).Massimo Filippi Roberta MessinaPublished Online:Dec 10 2024https://doi.org/10.1148/radiol.242978See also the article by Mehta et al in this issue.MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Martucci KT. Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder. Trends Neurosci 2024;47(6):418–431. Medline Google Scholar2. Volkow ND, McLellan AT. Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies. N Engl J Med 2016;374(13):1253–1263. Medline Google Scholar3. Rosenblum A, Marsch LA, Joseph H, Portenoy RK. Opioids and the treatment of chronic pain: controversies, current status, and future directions. Exp Clin Psychopharmacol 2008;16(5):405–416. Medline Google Scholar4. Mehta S, Peterson H, Ye J, et al. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024;313(3):e240514. Google Scholar5. Moningka H, Lichenstein S, Yip SW. Current understanding of the neurobiology of opioid use disorder: An overview. Curr Behav Neurosci Rep 2019;6(1):1–11. Medline Google Scholar6. Ranjbar H, Soti M, Banazadeh M, Saleki K, Kohlmeier KA, Shabani M. Addiction and the cerebellum with a focus on actions of opioid receptors. Neurosci Biobehav Rev 2021;131:229–247. Medline Google Scholar7. Corder G, Castro DC, Bruchas MR, Scherrer G. Endogenous and Exogenous Opioids in Pain. Annu Rev Neurosci 2018;41(1):453–473. Medline Google Scholar8. Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron 2007;55(3):377–391. Medline Google Scholar9. Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 2011;12(11):652–669. Medline Google ScholarArticle HistoryReceived: Oct 2 2024Revision requested: Oct 18 2024Revision received: Oct 20 2024Accepted: Oct 21 2024Published online: Dec 10 2024 FiguresReferencesRelatedDetailsAccompanying This ArticleAlterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use DisorderDec 10 2024Radiology Vol. 313, No. 3 Metrics Altmetric Score PDF download