已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Long‐term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta‐analysis

癫痫 智商 癫痫外科 荟萃分析 置信区间 儿科 边缘智力功能 医学 智力残疾 认知 心理学 物理疗法 精神科 内科学
作者
Ilona Stefanos‐Yakoub,Kevin Wingeier,Ulrike Held,Beatrice Latal,Elaine Wirrell,Mary Lou Smith,Georgia Ramantani
出处
期刊:Epilepsia [Wiley]
卷期号:65 (2): 251-265 被引量:4
标识
DOI:10.1111/epi.17834
摘要

In addition to the primary aim of seizure freedom, a key secondary aim of pediatric epilepsy surgery is to stabilize and, potentially, optimize cognitive development. Although the efficacy of surgical treatment for seizure control has been established, the long-term intellectual and developmental trajectories are yet to be delineated. We conducted a systematic review and meta-analysis of studies reporting pre- and postsurgical intelligence or developmental quotients (IQ/DQ) of children with focal lesional epilepsy aged ≤18 years at epilepsy surgery and assessed at >2 years after surgery. We determined the IQ/DQ change and conducted a random-effects meta-analysis and meta-regression to assess its determinants. We included 15 studies reporting on 341 patients. The weighted mean age at surgery was 7.1 years (range = .3-13.8). The weighted mean postsurgical follow-up duration was 5.6 years (range = 2.7-12.8). The overall estimate of the mean presurgical IQ/DQ was 60 (95% confidence interval [CI] = 47-73), the postsurgical IQ/DQ was 61 (95% CI = 48-73), and the change was +.94 IQ/DQ (95% CI = -1.70 to 3.58, p = .486). Children with presurgical IQ/DQ ≥ 70 showed a tendency for higher gains than those with presurgical IQ/DQ < 70 (p = .059). Higher gains were determined by cessation of antiseizure medication (ASM; p = .041), not just seizure freedom. Our findings indicate, on average, stabilization of intellectual and developmental functioning at long-term follow-up after epilepsy surgery. Once seizure freedom has been achieved, ASM cessation enables the optimization of intellectual and developmental trajectories in affected children.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉觅云应助爻解采纳,获得10
1秒前
1秒前
李健应助胡林采纳,获得10
3秒前
纸鸢发布了新的文献求助10
3秒前
打打应助科研通管家采纳,获得10
3秒前
3秒前
科研通AI5应助科研通管家采纳,获得10
3秒前
3秒前
orixero应助科研通管家采纳,获得10
3秒前
Smile发布了新的文献求助30
3秒前
利物鸟贝拉完成签到,获得积分10
4秒前
4秒前
hyr发布了新的文献求助10
5秒前
ohh发布了新的文献求助10
5秒前
Lamis完成签到 ,获得积分10
6秒前
17852573662完成签到,获得积分10
6秒前
7秒前
羊绮完成签到,获得积分10
8秒前
犇骉完成签到,获得积分10
8秒前
科目三应助kylin采纳,获得10
9秒前
10秒前
研友_QLXYgn发布了新的文献求助10
11秒前
汉堡包应助小方采纳,获得10
11秒前
12秒前
13秒前
kmkm发布了新的文献求助10
13秒前
乐乐应助快来和姐妹玩采纳,获得30
13秒前
lei完成签到,获得积分10
14秒前
胡林发布了新的文献求助10
16秒前
Smile完成签到,获得积分10
17秒前
李健应助豆豆欢欢乐采纳,获得10
18秒前
徐徐发布了新的文献求助10
19秒前
20秒前
故城完成签到 ,获得积分10
24秒前
墨川完成签到,获得积分10
24秒前
sjxbjrndkd完成签到 ,获得积分10
25秒前
jimi完成签到,获得积分10
26秒前
28秒前
29秒前
远山笑你完成签到 ,获得积分10
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976455
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203850
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806539