Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake

代谢物 代谢组学 尿 食品科学 食品集团 食物摄入量 化学 动物科学 生物 医学 内分泌学 生物化学 环境卫生 色谱法
作者
Mary C. Playdon,Lesley F. Tinker,Ross L. Prentice,Erikka Loftfield,Kathleen M. Hayden,Linda Van Horn,Joshua N. Sampson,Rachael Z. Stolzenberg‐Solomon,Johanna W. Lampe,Marian L. Neuhouser,Steven C. Moore
出处
期刊:The American Journal of Clinical Nutrition [Oxford University Press]
卷期号:119 (2): 511-526 被引量:4
标识
DOI:10.1016/j.ajcnut.2023.10.016
摘要

Metabolomics has the potential to enhance dietary assessment by revealing objective measures of many aspects of human food intake. Although metabolomics studies indicate that hundreds of metabolites are associated with dietary intake, correlations have been modest (e.g., r < 0.50), and few have been evaluated in controlled feeding studies. The aim of this study was to evaluate associations between metabolites and weighed food and beverage intake in a controlled feeding study of habitual diet. Healthy postmenopausal females from the Women's Health Initiative (N = 153) were provided with a customized 2-wk controlled diet designed to emulate their usual diet. Metabolites were measured by liquid chromatography tandem mass spectrometry in end-of-study 24-h urine and fasting serum samples (1293 urine metabolites; 1113 serum metabolites). We calculated partial Pearson correlations between these metabolites and intake of 65 food groups, beverages, and supplements during the feeding study. The threshold for significance was Bonferroni-adjusted to account for multiple testing (5.94 × 10−07 for urine metabolites; 6.91 × 10−07 for serum metabolites). Significant diet–metabolite correlations were identified for 23 distinct foods, beverages, and supplements (171 distinct metabolites). Among foods, strong metabolite correlations (r ≥ 0.60) were evident for citrus (highest r = 0.80), dairy (r = 0.65), and broccoli (r = 0.63). Among beverages and supplements, strong correlations were evident for coffee (r = 0.86), alcohol (r = 0.69), multivitamins (r = 0.69), and vitamin E supplements (r = 0.65). Moderate correlations (r = 0.50–0.60) were also observed for avocado, fish, garlic, grains, onion, poultry, and black tea. Correlations were specific; each metabolite correlated with one food, beverage, or supplement, except for metabolites correlated with juice or multivitamins. Metabolite levels had moderate to strong correlations with weighed intake of habitually consumed foods, beverages, and supplements. These findings exceed in magnitude those previously observed in population studies and exemplify the strong potential of metabolomics to contribute to nutrition research. The Women's Health Initiative is registered at clinicaltrials.gov as NCT00000611.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wenbin发布了新的文献求助10
刚刚
1秒前
2秒前
SciGPT应助zhudaxia采纳,获得10
2秒前
小熊星星发布了新的文献求助30
2秒前
4秒前
李健应助马绍清采纳,获得10
4秒前
缥缈逍遥完成签到 ,获得积分10
5秒前
自由莺发布了新的文献求助10
5秒前
冬瓜熊发布了新的文献求助10
5秒前
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
豆子应助科研通管家采纳,获得10
6秒前
爆米花应助科研通管家采纳,获得20
6秒前
CipherSage应助科研通管家采纳,获得10
6秒前
酷波er应助科研通管家采纳,获得10
6秒前
NPC应助科研通管家采纳,获得10
6秒前
852应助科研通管家采纳,获得30
6秒前
科研通AI2S应助科研通管家采纳,获得10
6秒前
bkagyin应助科研通管家采纳,获得10
6秒前
脑洞疼应助科研通管家采纳,获得10
7秒前
小强发布了新的文献求助10
7秒前
斯文尔阳发布了新的文献求助10
7秒前
吉岭茶完成签到,获得积分10
8秒前
8秒前
张坤完成签到,获得积分20
8秒前
9秒前
10秒前
11秒前
z123发布了新的文献求助10
12秒前
珍惜发布了新的文献求助10
14秒前
李健的小迷弟应助00采纳,获得10
16秒前
斯文尔阳完成签到,获得积分10
16秒前
小mol仙发布了新的文献求助10
18秒前
搞钱完成签到,获得积分10
19秒前
23秒前
Endeavor完成签到,获得积分10
24秒前
25秒前
zho应助斯文的傲珊采纳,获得10
25秒前
脑洞疼应助无限的时光采纳,获得10
25秒前
高分求助中
Sustainability in Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3076162
求助须知:如何正确求助?哪些是违规求助? 2729044
关于积分的说明 7507177
捐赠科研通 2377267
什么是DOI,文献DOI怎么找? 1260526
科研通“疑难数据库(出版商)”最低求助积分说明 611000
版权声明 597164