There is an established relationship between depression and increased risk for, and poorer outcomes of, comorbid medical conditions. This understanding was extended in a population-based cohort study by Dae Jong Oh, who looked at the role of depression on the progression of multimorbidity in older adults (reference). Multimorbidity is the presence of two or more chronic medical conditions in the same individual, complex multimorbidity is defined as the co-occurrence of three or more chronic conditions affecting three or more different body systems, and highly complex multimorbidity refers to chronic conditions affecting five or more body systems. Using data from the Korean Longitudinal Study on Cognitive Aging and Dementia, Dae Jong Oh assessed 2,486 persons aged 60 years and older at 2-year intervals for an average of 5.8 years and found a worsening of complex and highly complex multimorbidity in older adults, especially if the depression was severe or anhedonic. The questions that these data raise are: Why might this association occur and what can be done about it?