软骨
硫酸软骨素
软骨发生
再生(生物学)
材料科学
生物相容性
软骨细胞
骨关节炎
细胞外基质
自愈水凝胶
生物医学工程
体内
糖胺聚糖
细胞生物学
化学
解剖
医学
生物化学
病理
生物
高分子化学
生物技术
替代医学
冶金
作者
Xi Yuan,G. Li,Long Huang,Miao Zheng,J. Su,Junlai Wan,Haozhe Cheng,Hao Zhu,Xulin Jiang,Jun Xiao
标识
DOI:10.1016/j.matdes.2024.112656
摘要
Cartilage has limited self-repair ability, leading to osteoarthritis postinjury and ultimately physical disability in people. In addition, cartilage injury is accompanied by loss of extracellular matrix (ECM) and infiltration of inflammation, which makes cartilage regeneration more difficult. In this study, a hybrid hydrogel of hydroxypropyl chitin and oxidized chondroitin sulfate (HPCH-OCS) with injectable and thermosensitive properties was prepared by a Schiff base reaction. In vitro, the HPCH-OCS hydrogel showed desirable biocompatibility and bioactivity by promoting chondrogenic differentiation of stem cells, maintaining the chondrocyte phenotype, and inhibiting proteins related to cartilage ECM catabolism under inflammatory conditions. In vivo, the HPCH-OCS hydrogel combined with microfracture could effectively repair cartilage defects and promote cartilage regeneration. In conclusion, the HPCH-OCS hydrogel has good biological and mechanical properties, and its combination with microfracture provides an effective strategy for clinical cartilage regeneration.
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