Polysaccharides from Dendrobium officinale improve obesity‐induced insulin resistance through the gut microbiota and the SOCS3‐mediated insulin receptor substrate‐1 signaling pathway

Obesity induces insulin resistance and chronic inflammation, impacting human health. The relationship between obesity, gut microbiota, and regulatory mechanisms has been studied extensively. Dendrobium officinale polysaccharide (DOP), a traditional Chinese herbal medicine, potentially reduces insulin resistance. However, the mechanism through which DOP affects gut microbiota and alleviates obesity-induced insulin resistance in rats requires further investigation.