Polysaccharides from Dendrobium officinale improve obesity‐induced insulin resistance through the gut microbiota and the SOCS3‐mediated insulin receptor substrate‐1 signaling pathway

Dendrobium officinale polysaccharide regulated the gut microbiota, enhanced IRS-1 expression, and mitigated liver injury and insulin resistance due to a high-fat diet. These findings depict the potential anti-insulin resistance properties of DOP and offer further evidence for addressing obesity and its complications. © 2023 Society of Chemical Industry.