Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size

医学 心房颤动 孟德尔随机化 内科学 心脏病学 左心房扩大 冠状动脉疾病 人口 血压 心力衰竭 基因型 遗传变异 生物化学 窦性心律 化学 基因 环境卫生
作者
Vineet Agrawal,Ali Manouchehri,Nataraja Sarma Vaitinadin,Mingjian Shi,Minoo Bagheri,Deepak K. Gupta,Iftikhar J. Kullo,Yuan Luo,Elizabeth M. McNally,Megan J. Puckelwartz,Jane F. Ferguson,Quinn S. Wells,Jonathan D. Mosley
出处
期刊:Circulation-heart Failure [Lippincott Williams & Wilkins]
卷期号:17 (1) 被引量:1
标识
DOI:10.1161/circheartfailure.123.010557
摘要

Greater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not well known. Our study sought to identify genetic risk mechanisms affecting left atrial diameter (LAD) in a clinical cohort.Using Vanderbilt deidentified electronic health record, we studied 6163 females and 5993 males of European ancestry who had at least 1 LAD measure and available genotyping. A sex-stratified polygenic score was constructed for LAD variation and tested for association against 1680 International Classification of Diseases code-based phenotypes. Two-sample univariable and multivariable Mendelian randomization approaches were used to assess etiologic relationships between candidate associations and LAD.A phenome-wide association study identified 25 International Classification of Diseases code-based diagnoses in females and 11 in males associated with a polygenic score of LAD (false discovery rate q<0.01), 5 of which were further evaluated by Mendelian randomization (waist circumference [WC], atrial fibrillation, heart failure, systolic blood pressure, and coronary artery disease). Sex-stratified differences in the genetic associations between risk factors and a polygenic score for LAD were observed (WC for females; heart failure, systolic blood pressure, atrial fibrillation, and WC for males). By multivariable Mendelian randomization, higher WC remained significantly associated with larger LAD in females, whereas coronary artery disease, WC, and atrial fibrillation remained significantly associated with larger LAD in males.In a clinical population, we identified, by genomic approaches, potential etiologic risk factors for larger LAD. Further studies are needed to confirm the extent to which these risk factors may be modified to prevent or reverse adverse left atrial remodeling and the extent to which sex modifies these risk factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yx_cheng举报阳光青文求助涉嫌违规
3秒前
asdjha完成签到,获得积分20
4秒前
5秒前
大模型应助log采纳,获得10
6秒前
荔枝完成签到 ,获得积分10
9秒前
12秒前
12秒前
13秒前
14秒前
佳AOAOAO发布了新的文献求助10
15秒前
18秒前
18秒前
19秒前
小水发布了新的文献求助10
19秒前
严珍珍完成签到 ,获得积分10
19秒前
wanci应助阳光青文采纳,获得10
21秒前
Caliho完成签到,获得积分10
21秒前
ding发布了新的文献求助10
22秒前
ljkshr发布了新的文献求助10
23秒前
27秒前
愤怒的咖啡完成签到,获得积分10
28秒前
默默千亦完成签到,获得积分10
29秒前
xiaoxiaozhu发布了新的文献求助10
31秒前
明明明发布了新的文献求助30
32秒前
32秒前
道友请留步完成签到 ,获得积分10
33秒前
天天开心完成签到 ,获得积分10
33秒前
koukeika完成签到,获得积分10
34秒前
可靠数据线给可靠数据线的求助进行了留言
35秒前
36秒前
YouD关注了科研通微信公众号
37秒前
37秒前
37秒前
38秒前
某只兔子发布了新的文献求助10
39秒前
橙子发布了新的文献求助10
40秒前
chenhoe1212发布了新的文献求助10
40秒前
欧阳正义发布了新的文献求助10
40秒前
sunzhuxi发布了新的文献求助10
42秒前
冰可乐发布了新的文献求助10
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3967386
求助须知:如何正确求助?哪些是违规求助? 3512667
关于积分的说明 11164479
捐赠科研通 3247536
什么是DOI,文献DOI怎么找? 1793911
邀请新用户注册赠送积分活动 874758
科研通“疑难数据库(出版商)”最低求助积分说明 804498