Elucidating the Reversible and Irreversible Self-assembly Mechanisms of Low-Complexity Aromatic-Rich Kinked Peptides and Steric Zipper Peptides

Alternating stickers (Tyr) and spacers (Gly/Ser) drive the reversible assembly of LARKS peptides into highly dynamical oligomers, while hydrophobic patches in the steric zipper peptides promote the irreversible formation of β-sheet-rich assemblies.