Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides

Alternating stickers (Tyr) and spacers (Gly/Ser) drive the reversible assembly of LARKS peptides into highly dynamical oligomers, while hydrophobic patches in the steric zipper peptides promote the irreversible formation of β-sheet-rich assemblies.