Carbon monoxide-propelled nanomotors as an active treatment for renal injury

Many nanosystems have been prepared and implemented to treat acute kidney injury (AKI). Here, Au@MSN-encapsulated CORM-401 asymmetrical nanocarriers embedded with hyaluronic acid (HA, CD44-targeting agent) was constructed to treat renal tubule injury associated with AKI. The asymmetrical nanosystem could accumulate in the renal injury site through permeability and retention (EPR) behavior. Due to the impactful drug distribution in the kidney combined with the H2O2-responsive CO release, the administration of the asymmetrical nanosystem led to active treatment by nanomotor motion through asymmetrical CO release.