特雷彻-柯林斯综合征
颅面
干细胞
生物
胚胎干细胞
脂肪组织
再生医学
比较基因组杂交
生物信息学
诱导多能干细胞
颅面畸形
遗传学
医学
基因
基因组
内分泌学
作者
A L Costa,I Zanolla,F Zanotti,M Trentini,E Tiengo,A Greco Lucchina,C Mortellaro,M Giacomello,B Zavan
出处
期刊:PubMed
日期:2023-04-01
卷期号:27 (3 Suppl): 1-10
标识
DOI:10.26355/eurrev_202304_31311
摘要
Treacher Collins syndrome (TCS) is a rare congenital disorder of craniofacial development. TCS occurs with an incidence of 1:50,000, and more than 60% of TCS cases have no previous family history and arise as the result of de novo mutations. The high rate of de novo mutations, together with the extreme variability in the degree to which individuals can be affected, makes the provision of genetic counseling extremely complicated. Consequently, every case of TCS is unique and needs to be assessed individually. Patients with TCS frequently undergo multiple reconstructive surgeries from birth through adulthood, which rarely are fully corrective in the long-term. The nascent field of regenerative medicine offers the promise to improve some of these treatments. In particular, structural fat grafting (SFG) seems to be a good strategy not only to restore the normal volume and contour of the face, but also to provide a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. In this work, we present genetical analyses of ADSC affected by TCS.ADSCs from were analyzed for their stemness properties and shared many characteristics with those of a healthy subject. Screening of the genome of the TCS patient using array-Comparative Genomic Hybridization allowed us to identify some chromosomal imbalances that are probably associated with TCS.We found that some alterations, involving the TIMELESS gene, were usually associated with embryonic stem cells.With the aim to improve the final results, we need to consider combining knowledge of genetic alterations and expression profiles as a fundamental step before starting with surgical procedures.
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