体外
医学
小猎犬
凝结
麻醉
因子IX
微球
体外循环
外科
全血
内科学
化学工程
工程类
作者
Xin Song,Haifeng Ji,Yupei Li,Yang Xiong,Li Qiu,Rui Zhong,Meng Tian,Jayachandran N. Kizhakkedathu,Baihai Su,Qiang Wei,Weifeng Zhao,Changsheng Zhao
标识
DOI:10.1038/s41551-020-00673-x
摘要
During extracorporeal blood purification, anticoagulants are administered to prevent thrombogenesis. However, haemorrhagic complications owing to near-complete inactivation of blood coagulation and delayed recovery of haemostasis pose serious risks to patients. Here, we show in vitro and in beagle dogs that hydrogel microspheres that adsorb the coagulation factors VIII, IX and XI provide transient blood thinning when placed in the extracorporeal circuit before blood purification. The microspheres inhibited the activities of the coagulation factors by levels (~8-30%) similar to those occurring in mild haemophilia. On its reintroduction into the animal, the purified pseudo-haemophilic blood favoured faster recovery of haemostasis. The transient blood-thinning strategy may increase the safety of clinical blood-purification procedures.
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