Inspired by the inflammation of the intervertebral disc degene ration microenvironment, in article number 2006333, Bruno Sarmento, Wenguo Cui, Liang Chen, and co-workers design antagonist-functionalized injectable porous microspheres with functions of modulating inflammation responses and regulating extracellular matrix metabolism balance to satisfy the specific demand on early-stage restoration of the intervertebral disc microenvironment and its regeneration.