尼莫地平
胃-
色谱法
化学
医学
内科学
有机化学
钙
回流
疾病
作者
Mai Mamdouh,Ahmed A. Donia,Ebtessam Essa,Gamal M. El Maghraby
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2019-10-14
卷期号:16 (9): 862-871
被引量:8
标识
DOI:10.2174/1567201816666191014102531
摘要
Nimodipine is a calcium channel blocker frequently used in critical care settings. It is mainly absorbed in the upper gastrointestinal tract. Accordingly, the development of gastroretentive formulation will be beneficial. The benefit would be maximized for critical care patients if the developed system was in liquid form to facilitate the administration through nasogastric tubing.Development of gastro-retentive liquid oral controlled release formulation of nimodipine through in situ gellation.Nimodipine dissolution was improved by solid dispersion (SD) using poloxamer 407. Sodium alginate solutions (1, 1.5 and 2%w/v) were loaded with the optimized SD microparticles. Carboxymethylcellulose was added to modulate the release and to augment mucoadhesion power. All in situ gelling alginate solutions were characterized regarding viscosity, gelling capacity and drug release. SD microparticles showed considerable improvement in nimodipine dissolution.All alginate systems were pourable. Increasing alginate concentration increased the gelling capacity and reduced drug release rate. The addition of carboxymethylcellulose produced greater control over drug release rate. X-ray radiography showed successful stomach-retention over 8 hours in rabbits, which correlates with the controlled release pattern of the developed systems.The study provides the formulator with a range of gastroretentive controlled release formulations of nimodipine while maintaining the convenience of administration through nasogastric tubing with the potential for enhanced bioavailability.
科研通智能强力驱动
Strongly Powered by AbleSci AI