Research progress of plasminogen activator inhibitor-1 in several diseases

Plasminogen activator inhibitor-1 (PAI-1) is derived from the serine protease inhibitor superfamily ensuring normal coagulation function by inhibiting the activity of plasmin and degradation of extracellular matrix.It involves pathological and physiological processes such as cellular migration, thrombosis, and angiogenesis, participating in the development of diseases.This paper reviews the related researches on the PAI-1 in the development of thrombosis, tumor and respiratory diseases, and tries to provide ideas for studies on relationship between PAI-1 and related diseases. Key words: Plasminogen activator inhibitor-1; Inflammation; Fibrosis