[Exosome-Mediated Small RNA Delivery For Gene Therapy].

Small RNAs,including small interfering RNAand microRNA,are emerging as promising ther-apeutic drugs against a wide array of diseases.Current techniques for small RNA transfer use viruses or synthetic agents as delivery vehicles,however,these kinds of vehicles have a high toxicity and low target-specific.Exosomes ,natural nanocarriers derived from endogenous cells ,have the intrinsic ability to trav-erse biological barriers and to naturally transport functional small RNAs between cells.Exosome-based de-livery of small RNAs may provide an untapped source of effective delivery strategy to overcome impedi-ments such as inefficiency,unspecificity and immunogenic reactions,and exosomes potentially represent a novel and exciting delivery vehicle.In this review,we provide an update and overview of the new find-ings that reveal the potential applications of exosome-based small RNA delivery as therapeutics in clinical settings.