苯硼酸
硼酸
碳纤维
纳米颗粒
石墨烯
纳米技术
化学
生物相容性
细胞毒性
氨基酸
材料科学
生物物理学
组合化学
催化作用
生物化学
有机化学
生物
体外
复合材料
复合数
作者
Yu Yu Aung,Alfinda Novi Kristanti,Siti Qamariyah Khairunisa,Nasronudin Nasronudin,Mochamad Zakki Fahmi
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2020-07-01
卷期号:6 (8): 4490-4501
被引量:36
标识
DOI:10.1021/acsbiomaterials.0c00508
摘要
Current antiretroviral HIV therapies continue to have problems related to procedural complications, toxicity, and uncontrolled side effects. In this study, amino phenylboronic acid-modified carbon dots (APBA-CDs) were introduced as a new nanoparticle-based on gp120 targeting that inhibits HIV-1 entry processes. Prolonged by simple pyrolysis for preparing carbon dots, this report further explores attributing amino phenylboronic acid on carbon dots, which prove the formation of graphene-like structures on carbon dots and boronic acid sites, thereby enabling the enhancement of positive optical properties through photoluminescent detection. Aside from performing well in terms of biocompatibility and low cytotoxicity (the CC50 reach up to 11.2 mg/mL), APBA-CDs exhibited superior capabilities in terms of prohibiting HIV-1 entry onto targeted MOLT-4 cells recognized by the delimitations of syncitia formation and higher ATP signal rather than bare carbon dots. The modified carbon dots also promote dual-action on HIV-1 treatment by both intracellularly and extracellularly viral blocking by combining with the Duviral drug, along with compressing p24 antigen signals that are better than APBA-CDs and Duviral itself.
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