The Effect of Aerobic Training and Supplementation of Curcumin on the Glycemic Markers and Level of Myeloperoxidase Enzyme of Overweight Women

Diabetes and cardiovascular disease are the most common diseases in the world. Diabetes has many complications, and heart disease causes deaths worldwide. This study was aimed to investigate the effect of curcumin supplementation alone and with aerobic training on Body Mass Index (BMI), insulin resistance and myeloperoxidase (MPO) level in overweight women . Material and method: In this randomized double-blind placebo-controlled trial, forty healthy sedentary overweight females age 30-45 and BMI 25-30 kg/m2, were assigned to four groups of ten subjects each: supplementation (Cur), (Pla), Cur+aerobic training (Tra) and Pla+Tra. The aerobic training program comprised 3 days per week and Curcumin or placebo (500 mg/day) were administered in Cur and Cur+Tra groups in 8 weeks. Before and after intervention, BMI, HOMA-IR (Homeostatic Model Assessment-Insulin Resistance) and MPO enzyme were measured. ANOVA and ANCOVA was used to assess differences between the groups . Results: the within-group analysis showed no significant difference in BMI, HOMA-IR and MPO in four groups (P>0.05). Aerobic training and curcumin supplementation had no significant effect on BMI, HOMA-IR, and MPO levels in overweight middle-aged women (P>0.05). Conclusions: These finding suggest the combination of curcumin supplementation with aerobic training have no significant effect on BMI, HOMA-IR, and MPO levels in overweight middle-aged women. Further studies with different doses and longer interventions are needed to clarify the results.