医学
三叉神经痛
随机对照试验
生活质量(医疗保健)
置信区间
麻醉
神经病理性疼痛
外科
内科学
护理部
作者
Hugo Sterman-Neto,Cristiane Yoko Fukuda,Kleber Paiva Duarte,Valquíria Aparecida da Silva,Antônia Lilian de Lima Rodrigues,Ricardo Galhardoni,Sílvia Regina Dowgan Tesseroli de Siqueira,José Tadeu Tesseroli de Siqueira,Manoel Jacobsen Teixeira,Daniel Ciampi de Andrade
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:2020-09-16
卷期号:162 (3): 919-929
被引量:32
标识
DOI:10.1097/j.pain.0000000000002070
摘要
Abstract Surgical procedures are necessary in up to 50% of trigeminal neuralgia patients. Although radiofrequency (RF) is more widely used, it is associated with high intraprocedural costs and long technical learning time. Other simpler procedures such as balloon compression (BC) require a lower training period and have significant lower costs. We evaluated the effects of BC and RF in pain control in primary trigeminal neuralgia in a randomized, double-blinded, head-to-head trial. Individuals were randomly allocated in 1 of 2 groups: BC and RF. Throughout pain, psychological and quality of life measurements were performed at baseline and after surgery. The main outcome was the worst pain in the last 24 hours (0-10) at 6 months postoperatively. After the inclusion of half of the estimated sample, a preplanned interim analysis was performed when 33 patients (62.1 ± 9.4 y.) completed the study. Pain intensity (confidence interval [CI] 95% 0.6 to 3.8, and −0.6 to 2.2, for BC and RF) did not significantly differ. Complications, interference of pain in daily life (CI 95% −0.1 to 2.3 and −0.4 to 2.3, for BC and RF), neuropathic pain symptoms (CI 95% 1.7 to 3.6 and 3.0 to 5.7, for BC and RF), mood (CI 95% 4.8 to 11.5 and 5.5 to 15.1, BC and RF, respectively), medication use, and quality of life (CI 95% 80.4 to 93.1 and 83.9 to 94.2, for BC and RF) were also not different. Radiofrequency presented more paresthetic symptoms than BC at 30 days after intervention. Based on these results, the study was halted due to futility because BC was not superior to RF.
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