Significance of nanomaterials in electrochemical glucose sensors: An updated review (2016-2020)

The last decade has witnessed an immense demand for the development of new glucose biosensors. The research has mainly focused on achieving biocompatible and improved sensing capabilities as compared to the current technologies, which opens new directions toward more efficient glucose sensors. These sensing platforms have been continuously evolving with the contribution of novel materials, such as gold, platinum, metal alloys/adatom, graphene, composites and glucose-specific organic materials, owing to their electrocatalytic response to the oxidation of glucose. The chief motive of this review is to cover the recent advances on enzymatic and non-enzymatic glucose sensors evolved in the last four years. We discuss the sensor fabrication methods, the materials and nanostructures involved, the detection principles and the performance of the sensors in whole blood, saliva, urine or interstitial fluids in detail.