The Effect of pH on the Extracellular Matrix and Biofilms

蛋白酵素 伤口愈合 细胞外基质 慢性伤口 生物膜 蛋白酶 医学 炎症 化学 微生物学 外科 生物 免疫学 生物化学 细菌 遗传学
作者
Eleri M. Jones,Christine A. Cochrane,Steven L. Percival
出处
期刊:Advances in wound care [Mary Ann Liebert]
卷期号:4 (7): 431-439 被引量:330
标识
DOI:10.1089/wound.2014.0538
摘要

Significance: Chronic wounds become caught in a state of inflammation causing an increase in levels of degrading proteases, which destroy components of the extracellular matrix (ECM) that are essential for the wound healing process. This review aims to highlight and provide readers with an overview of what is currently known about the role of pH and its effect on the ECM and biofilms within healing and nonhealing wounds. Recent Advances: The pH profiles of healthy skin, acute wounds, and chronic wounds differ significantly. Chronic wounds have an alkaline pH whereas healthy skin has a slightly acidic pH. Although there is evidence on the effect of pH on protease production and bacterial proliferation in wounds, there is little evidence to show its effect on ECM synthesis and degradation. Critical Issues: The implications for the complex nature of chronic wounds are that no single treatment is relevant for all wounds, but rather a combination of methodologies must be adopted. It is known that pH of a wound reduces throughout the stages of healing, suggesting that wound pH measurements could be beneficial to identify nonhealing wounds earlier and decide on the most appropriate course of treatment. Future Direction: Wound healing is a very complex process with multiple factors known to play a role. All aspects of the nonhealing wound (defective ECM, pH, microbial invasion, and excess proteases) need to be taken into account when investigating or clinically treating a chronic wound.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
bzssyy发布了新的文献求助10
刚刚
3秒前
可爱的函函应助十月采纳,获得10
3秒前
4秒前
wuyu完成签到,获得积分10
4秒前
风笛发布了新的文献求助10
5秒前
Binbin完成签到,获得积分10
6秒前
一二三三完成签到,获得积分10
8秒前
流苏完成签到,获得积分10
8秒前
凉兮完成签到,获得积分10
9秒前
Deila完成签到 ,获得积分10
10秒前
10秒前
Zeon723完成签到 ,获得积分10
11秒前
晨子完成签到 ,获得积分10
11秒前
大七完成签到 ,获得积分10
11秒前
11秒前
李健的小迷弟应助tong采纳,获得10
13秒前
便宜小师傅完成签到 ,获得积分10
17秒前
陈军应助不甜采纳,获得60
17秒前
18秒前
18秒前
19秒前
20秒前
充电宝应助joy12138采纳,获得30
21秒前
wuhao完成签到 ,获得积分10
25秒前
秀某完成签到 ,获得积分10
26秒前
浮生若梦完成签到 ,获得积分10
27秒前
共享精神应助tanxiao采纳,获得10
27秒前
28秒前
话多白菜发布了新的文献求助10
28秒前
29秒前
无花果应助浏阳河采纳,获得10
29秒前
xiaoyun2852给奋斗的凌青的求助进行了留言
29秒前
29秒前
栗爷完成签到,获得积分0
31秒前
31秒前
33秒前
35秒前
bkagyin应助科研通管家采纳,获得10
36秒前
科研通AI2S应助科研通管家采纳,获得10
36秒前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
Sustainability in ’Tides Chemistry 1500
中国有机(类)肥料 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3060283
求助须知:如何正确求助?哪些是违规求助? 2715805
关于积分的说明 7446827
捐赠科研通 2361491
什么是DOI,文献DOI怎么找? 1251506
科研通“疑难数据库(出版商)”最低求助积分说明 607767
版权声明 596475