The Effect of pH on the Extracellular Matrix and Biofilms

蛋白酵素 伤口愈合 细胞外基质 慢性伤口 生物膜 蛋白酶 医学 炎症 化学 微生物学 外科 生物 免疫学 生物化学 细菌 遗传学
作者
Eleri M. Jones,Christine A. Cochrane,Steven L. Percival
出处
期刊:Advances in wound care [Mary Ann Liebert]
卷期号:4 (7): 431-439 被引量:330
标识
DOI:10.1089/wound.2014.0538
摘要

Significance: Chronic wounds become caught in a state of inflammation causing an increase in levels of degrading proteases, which destroy components of the extracellular matrix (ECM) that are essential for the wound healing process. This review aims to highlight and provide readers with an overview of what is currently known about the role of pH and its effect on the ECM and biofilms within healing and nonhealing wounds. Recent Advances: The pH profiles of healthy skin, acute wounds, and chronic wounds differ significantly. Chronic wounds have an alkaline pH whereas healthy skin has a slightly acidic pH. Although there is evidence on the effect of pH on protease production and bacterial proliferation in wounds, there is little evidence to show its effect on ECM synthesis and degradation. Critical Issues: The implications for the complex nature of chronic wounds are that no single treatment is relevant for all wounds, but rather a combination of methodologies must be adopted. It is known that pH of a wound reduces throughout the stages of healing, suggesting that wound pH measurements could be beneficial to identify nonhealing wounds earlier and decide on the most appropriate course of treatment. Future Direction: Wound healing is a very complex process with multiple factors known to play a role. All aspects of the nonhealing wound (defective ECM, pH, microbial invasion, and excess proteases) need to be taken into account when investigating or clinically treating a chronic wound.

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