苯氮卓类
化学
苯扎地平
分子内力
戒指(化学)
立体化学
亲核取代
组合化学
有机化学
作者
Vladímir V. Kouznetsov,Alirio Palma,Claude Ewert
标识
DOI:10.2174/1385272013375391
摘要
This review covers recent developments in the area of partially reduced 2-benzazepines, particularly synthesis and their main applications. The first chapter discusses the principal routes (ring-closure methods with formation of C-N or C-C bonds as well as ring expansion methods) to obtain these heterocycles. The second chapter covers total syntheses of the alkaloids galanthamine, lycoramine, narwedine and clavicipitic acid which all contain the 2-benzazepine core structure. At the end of the chapter, approaches to the homoberbine and ribasine skeleton are given. Additional information is provided for synthesis of medicinally important 8,9-dichloro-2,3,4,5-tetrahydro- 1H-2-benzazepine. Keywords: 2- Benzazepines, alkaloids galanthamine, Tetrahydrobenzazepines, acetylcholinesterase, intramolecular nucleophilic substitution, Friedel-Crafts intramolecular acylation, Pictet-Spengler, antiaggregatory, photochemical cyclisation, Clavicipitic acids
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