神经质
失眠症
萧条(经济学)
C反应蛋白
内科学
抑郁症状
心理学
全身炎症
临床心理学
炎症
医学
焦虑
精神科
人格
经济
宏观经济学
社会心理学
作者
Danica C. Slavish,Jennifer E. Graham‐Engeland,Joshua M. Smyth,Daniel J. Taylor,Orfeu M. Buxton
标识
DOI:10.1080/08870446.2018.1500577
摘要
Objective: Insomnia is associated with elevated inflammation; however, studies have not investigated if this relationship is confounded with depression and neuroticism, which are associated with insomnia and inflammation. The current study examined the association of insomnia symptoms with C-reactive protein (CRP) and with interleukin-6 (IL-6), independently and after controlling for depressive symptoms and neuroticism. Design: Fifty-two young adults (mean age = 25.2 ± 3.9 years, 52% female) completed a baseline survey to assess psychological characteristics, followed by a plasma blood draw. Main outcome measures: Plasma CRP and IL-6. Results: When examined alone, insomnia symptoms were significantly associated with elevated CRP (β = 0.52; R2 = 0.27), as was neuroticism (β = 0.41, R2 = 0.17), but not depressive symptoms (β = 0.21, R2 = 0.05). The association between insomnia symptoms and CRP remained significant when depressive symptoms and neuroticism were entered into the model simultaneously; this model did not explain more variance than the model with insomnia symptoms alone. No variables were associated with IL-6. Conclusions: Results suggest that insomnia symptoms are independently associated with elevated CRP in young adults, even after controlling for presumed overlapping psychological constructs. Findings highlight the potential importance of treating insomnia to reduce systemic inflammation.
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