<p>Prognostic significance of FA score based on plasma fibrinogen and serum albumin in patients with epithelial ovarian cancer</p>

纤维蛋白原 医学 内科学 白蛋白 胃肠病学 卵巢癌 接收机工作特性 癌症 病理
作者
Yuan Li,Jiani Yang,Shanshan Cheng,Yu Wang
出处
期刊:Cancer management and research [Dove Medical Press]
卷期号:Volume 11: 7697-7705 被引量:9
标识
DOI:10.2147/cmar.s211524
摘要

To evaluate the significance of fibrinogen and albumin (FA) score based on preoperative peripheral blood plasma fibrinogen and serum albumin in the prognosis of patients with epithelial ovarian cancer (EOC).Patients' clinicopathological data of 186 cases of EOC were retrospectively collected, and these patients were divided into three groups according to their FA scores (both plasma fibrinogen and serum albumin abnormal were allocated a score of 2; one of them abnormal were allocated a score of 1; neither of them abnormal were allocated a score of 0; optimal cut-off point is taken as the critical point whether the value is abnormal or not). Correlation between FA score in patients with EOC as well as clinicopathological features and overall survival (OS) was analyzed.(1) Receiver operating characteristic curve showed that the optimal cut-off point of plasma fibrinogen in the preoperative peripheral blood of patients with EOC was 3.63 g/L. The optimal cut-off point for serum albumin level was 42.45 g/L. (2) There was no significant difference in age, tumor size, neutrophil count, lymphocyte count, C reactive protein and preoperative tumor marker CA125 between the three groups (FA score=0, FA score=1, FA score=2) (P>0.05). However, there was statistically significant difference in tumor grade, tumor stage and the presence of lymph node metastasis between different FA scoring groups (P<0.05). (3) Univariate and multivariate analyses showed that tumor size, tumor grade, tumor stage, plasma fibrinogen, serum albumin, FA score and tumor marker CA125 were statistically correlated with OS of EOC patients after surgery (P<0.05). The complex index FA score is superior to the single plasma fibrinogen and serum albumin when it comes to predicting prognosis. (4) FA score can better predict the prognosis of postoperative patients with EOC whose tumor size is ≥6 cm, whose EOC is advanced (stages III-IV) (P=0.0138) and whose tumor stage is medium or high grade (P=0.0005).FA score is closely related to the clinicopathological characteristics and OS of patients with EOC and is an independent risk factor indicating the prognosis of EOC patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
诚心的扬关注了科研通微信公众号
1秒前
3秒前
嗨嗨害完成签到,获得积分10
4秒前
吧啦吧啦完成签到,获得积分10
4秒前
5秒前
6秒前
zero完成签到,获得积分10
7秒前
小二郎应助momo采纳,获得10
8秒前
hh完成签到 ,获得积分10
8秒前
大大完成签到 ,获得积分10
8秒前
8秒前
量子星尘发布了新的文献求助10
10秒前
YI发布了新的文献求助10
10秒前
Stardust完成签到 ,获得积分10
11秒前
zero发布了新的文献求助10
11秒前
共享精神应助果粒多采纳,获得10
12秒前
ali应助史念薇采纳,获得10
14秒前
16秒前
海城好人完成签到,获得积分10
16秒前
17秒前
默默完成签到,获得积分10
17秒前
维尼完成签到,获得积分20
17秒前
19秒前
文档发布了新的文献求助10
20秒前
20秒前
科目三应助Loik采纳,获得10
21秒前
22秒前
22秒前
24秒前
24秒前
果粒多发布了新的文献求助10
25秒前
27秒前
29秒前
李泽雄完成签到,获得积分10
30秒前
gsq发布了新的文献求助30
30秒前
momo发布了新的文献求助10
30秒前
wdy111应助学习鱼采纳,获得20
32秒前
32秒前
G哟X完成签到 ,获得积分10
33秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989297
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253893
捐赠科研通 3270097
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809158