A review on the immunomodulatory activity of Acanthopanax senticosus and its active components

人参 传统医学 根茎 中医药 医学 五加科 药理学 免疫系统 水提取物 外周血单个核细胞 生物 免疫学 生物化学 体外 病理 替代医学
作者
Kit-Man Lau,Grace Gar‐Lee Yue,Yuk‐Yu Chan,Hin-Fai Kwok,Si Gao,Chun‐Wai Wong,Clara Bik‐San Lau
出处
期刊:Chinese Medicine [Springer Nature]
卷期号:14 (1) 被引量:49
标识
DOI:10.1186/s13020-019-0250-0
摘要

Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of Acanthopanax senticosus, is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as an adaptogen to enhance physical and mental performance for the sake of normal physiological functioning of human bodies under stress. In the theory of traditional Chinese medicine, Ciwujia can strengthen the spleen that is an essential organ for immunological response. Its traditional applications include inflammation, fatigue and cancer in which the immune-regulating function is always involved. In this article, the immunomodulatory activities of Ciwujia extracts, fractions and pure compounds were extensively reviewed first. Then, the possibility of upgrading the chemical markers to bioactive markers was explored. Finally, the potency of aqueous extract and ethanol extract in regulating cytokines production from human peripheral blood mononuclear cells was compared. We conclude that although various phytochemicals such as isofraxidin, syringin and eleutheroside E from Ciwujia have been shown to modulate immunological functions, the aqueous extract of Ciwujia as a whole possesses the most potent efficacy. Therefore, aqueous (rather than ethanol) extract of Ciwujia should be used in order to benefit from its immunomodulatory properties.
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