斑马鱼
细胞生物学
生物
平衡
原肠化
免疫系统
淋巴细胞
先天免疫系统
突变体
免疫学
胚胎发生
遗传学
胚胎
基因
作者
Lei Zhao,Jiaqi Tan,Dan Li,Lijun Jiang,Tongjuan Li,Yi Yang,Gaoxiang Wang,Zhen Shang,Jue Wang,Jianfeng Zhou
标识
DOI:10.1016/j.bbrc.2019.02.148
摘要
Zinc (Zn) is an essential trace element that modulate innate and acquired immune responses, and its deficiency triggers lymphopenia. However, the precise mechanisms underlying zinc-mediated lymphocyte maintenance have not been well clarified. Here, we have successfully generated a zip6-null mutant zebrafish line using TALENs. The Zip6-null mutant zebrafish developed normally during gastrulation. Loss of zip6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels. And the zip6 deficiency increases caspase-related cell apoptosis in both zebrafish cells and human T cells. Our results suggest that ZIP6 plays a critical part in T cell development, and enhance our understanding of Zn homeostasis and immune system maintenance.
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