表观遗传学
新陈代谢
嘌呤代谢
细胞代谢
翻译(生物学)
生物
生物化学
细胞代谢
细胞生物学
基因
信使核糖核酸
酶
作者
Yuxiang Zheng,Lewis C. Cantley
摘要
Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.
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