双环分子
化学
立体化学
戒指尺寸
戒指(化学)
有机化学
作者
Hayato Suzuki,Hiroshi Morita,Shigeo Iwasaki,Jun’ichi Kobayashi
出处
期刊:Tetrahedron
[Elsevier]
日期:2003-07-01
卷期号:59 (28): 5307-5315
被引量:64
标识
DOI:10.1016/s0040-4020(03)00762-2
摘要
Six new bicyclic peptides, celogentins D–H (1–5) and J (6) have been isolated from the seeds of Celosia argentea, and the structures including its absolute stereochemistry were determined by using extensive NMR methods and chemical means. Celogentins E–H (2–5) and J (6) showed potent inhibition of tubulin polymerization, while the inhibitory activity of celogentin D (1) was modest. Structure–activity relationship study indicates that ring size of the bicyclic ring system including unusual βs-Leu, Trp, and His residues would be important for their biological activity.
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