a email: xieyongpeng@163.com b email:ygyang_1982@163.com Abstract. MOOCs inherit the concept of open and shared knowledge of OER and achieve the global share of quality education resources successfully and efficiently. They are a breakthrough innovation for learning ways and methods. The disadvantages of the traditional teaching mode of analytical chemistry is mainly reflected in two aspects. On the one hand, the traditional teaching method is too conservative. On the other hand, quality teaching resources is insufficient and teaching content is disconnected from times. MOOCs bring infinite vitality and potential to the teaching reform of analytical chemistry. There are three sides to improve analytical chemistry teaching under the background of MOOCs. First, teachers and students should change the role of themselves and improving the students' initiative in learning. Secondly, teachers should reconstruct the knowledge structure of analytical chemistry. Finally, teachers should guide the autonomous learning and autonomous experiment design in virtue of the blended learning mode.