清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Microwave hyperthermia and its effect on tumor blood flow in rats.

热疗 血流 血管舒张 后肢 微循环 血管收缩 骨骼肌 化学 血管阻力 血压 内科学 医学 内分泌学 解剖
作者
Shashi Shrivastav,William G. Kaelin,William T. Joines,Randy L. Jirtle
出处
期刊:PubMed 卷期号:43 (10): 4665-9 被引量:33
链接
标识
摘要

The present experiments were designed to investigate the effects of microwave hyperthermia on the microcirculation of normal and malignant tissues in female Wistar/Furth rats. During the localized heating of anesthetized rats, the hind leg musculature surrounding the SMT-2A mammary adenocarcinoma was heated at either 39 degrees, 42 degrees, or 44 degrees. Neither the body temperature, cardiac output, heart rate, nor systemic arterial pressure were significantly altered by heating at these temperatures for up to 60 min. Our results demonstrate that the changes in vascular resistance which occur during hyperthermic treatment are dependent upon both the temperature and the tissue heated. When the tumor (1.2 g)-bearing hind leg was heated to 39 degrees, the tissue vascular resistance and blood flow were unaltered even after 45 min of heating. Heating at 42 degrees and 44 degrees caused an initial vasoconstriction in the tumor, which was subsequently followed by marked vasodilation. This transient initial decrease in blood flow was not, however, observed in the skeletal muscle at either temperature. With prolonged heating at 42 degrees and 44 degrees, the muscle blood flow increased by a factor of 1.6 and 3.2, respectively. In contrast, malignant tissue blood flow increased by a factor of 1.3, and this maximum increase was observed only when the tumor was heated at 44 degrees for more than 45 min. Nevertheless, even with this proportionally greater increase in the blood flow of the surrounding normal tissue, it was never more than that of the tumor. As a consequence, the tumor temperature during hyperthermic treatment was always either less than or equal to that in the surrounding normal musculature.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
12秒前
21秒前
Raunio完成签到,获得积分10
22秒前
巫巫巫巫巫完成签到 ,获得积分10
23秒前
qq完成签到 ,获得积分10
28秒前
小鱼完成签到 ,获得积分10
39秒前
火星上惜天完成签到 ,获得积分10
44秒前
科目三应助尔尔采纳,获得10
48秒前
naczx完成签到,获得积分0
54秒前
Mt完成签到,获得积分10
54秒前
天问完成签到 ,获得积分10
55秒前
59秒前
59秒前
huanghe完成签到,获得积分10
1分钟前
尔尔发布了新的文献求助10
1分钟前
研友_08oa3n完成签到 ,获得积分10
1分钟前
L_x完成签到 ,获得积分10
1分钟前
1分钟前
gobi完成签到 ,获得积分10
1分钟前
胖小羊完成签到 ,获得积分10
1分钟前
2分钟前
e任思完成签到 ,获得积分10
2分钟前
2分钟前
KrisTina完成签到 ,获得积分10
2分钟前
燕山堂完成签到 ,获得积分10
2分钟前
Alan应助阿玉采纳,获得10
2分钟前
mochalv123完成签到 ,获得积分10
3分钟前
3分钟前
蓝意完成签到,获得积分0
3分钟前
笑面客完成签到,获得积分10
3分钟前
忧虑的绮兰完成签到,获得积分20
3分钟前
3分钟前
诺亚方舟哇哈哈完成签到 ,获得积分0
3分钟前
dent强完成签到 ,获得积分10
3分钟前
3分钟前
yuntong完成签到 ,获得积分10
3分钟前
4分钟前
曾经不言完成签到 ,获得积分10
4分钟前
lod完成签到,获得积分10
4分钟前
高分求助中
Medicina di laboratorio. Logica e patologia clinica 600
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
Ultrasound-guided bilateral erector spinae plane block in the management of postoperative analgesia in living liver donors: a randomized, prospective study 400
Functional Syntax Handbook: Analyzing English at the Level of Form (作者 Robin Fawcett ) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3215722
求助须知:如何正确求助?哪些是违规求助? 2864341
关于积分的说明 8142282
捐赠科研通 2530579
什么是DOI,文献DOI怎么找? 1364757
科研通“疑难数据库(出版商)”最低求助积分说明 644293
邀请新用户注册赠送积分活动 616852