神经突
神经生长因子
细胞生物学
磷酸化
肌球蛋白轻链激酶
磷酸酶
Rho相关蛋白激酶
肌球蛋白
生长锥
化学
生物
体外
生物化学
轴突
受体
作者
Akikazu Fujita,Yasuyo Hattori,Tadayoshi Takeuchi,Yoichi Kamata,Fumiaki Hata
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2001-11-01
卷期号:12 (16): 3599-3602
被引量:26
标识
DOI:10.1097/00001756-200111160-00045
摘要
The relationship between phosphorylation of myosin light chain (MLC) and neurite outgrowth induced by nerve growth factor (NGF) was studied in PC12 cells. Inhibitors of Rho kinase, HA-1077 or Y-27632 also induced neurite outgrowth. As already reported botulinum exoenzyme C3 which inactivates Rho protein also induced neurite outgrowth. Calyeulin A, an inhibitor of phosphatase counteracted both NGF- and C3- induced neurite outgrowth. Treatments of both NGF and C3 resulted in significant and transient decrease in phosphorylated MLC. These results suggest that NGF induces neurite outgrowth of PC12 by a transient decrease in phosphorylated MLC which is brought about by activation of MLC phosphatase via inhibition of Rho-Rho kinase pathway.
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