青霉胺
产量(工程)
化学
青霉素
水溶液
核化学
降级(电信)
青霉素
无机化学
药物化学
抗生素
有机化学
生物化学
冶金
材料科学
电信
计算机科学
作者
A. E. Bird,Keith R. Jennings,A. C. MARSHALL
标识
DOI:10.1111/j.2042-7158.1986.tb03382.x
摘要
The degradation of several penicillins in unbuffered aqueous solution produces N-formylpenicillamine, in some cases in high yield. Very little or no penicillamine is formed under these conditions. N-Formylpenicillamine was produced from benzylpenicillin at pH values between 2.5 and 7, with a maximum yield of 30% at pH 5, whereas penicillamine was produced only at pH 5 or below in a yield of less than 1%. Benzylpenicillenic acid at pH 5 gave a 20% yield of N-formylpenicillamine and no penicillamine whereas benzylpenicilloic, penilloic and penillic acids gave no N-formylpenicillamine and a small amount of penicillamine.
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