生物
向性
病毒学
病毒
发病机制
伽马赫氏病毒亚科
免疫学
免疫系统
组织向性
爱泼斯坦-巴尔病毒
疱疹病毒科
慢性感染
病毒病机
B细胞
病毒复制
病毒性疾病
抗体
作者
Erik S. Barton,Pratyusha Mandal,Samuel H. Speck
标识
DOI:10.1146/annurev-immunol-072710-081639
摘要
Gammaherpesviruses are lymphotropic viruses that are associated with the development of lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most known gammaherpesviruses establish latency in B lymphocytes. Research on Epstein-Barr virus (EBV) and murine gammaherpesvirus 68 (MHV68/γHV68/MHV4) has revealed a complex relationship between virus latency and the stage of B cell differentiation. Available data support a model in which gammaherpesvirus infection drives B cell proliferation and differentiation. In general, the characterized gammaherpesviruses exhibit a very narrow host tropism, which has severely limited studies on the human gammaherpesviruses EBV and Kaposi's sarcoma–associated herpesvirus. As such, there has been significant interest in developing animal models in which the pathogenesis of gammaherpesviruses can be characterized. MHV68 represents a unique model to define the effects of chronic viral infection on the antiviral immune response.
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